Article
A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome.
The Journal of investigative dermatology - 1 Jan 1991
Abrams J T, Lessin S, Ghosh S K, Ju W, Vonderheid E C, Nowell P, Murphy G, Elfenbein B, DeFreitas E
Abstract excerpt
The reported inability to establish long-term T-cell lines from the blood of cutaneous T-cell lymphoma patients with circulating neoplastic T cells has hindered the development of an in vitro system to investigate Sézary syndrome. We have established a rapidly proliferating T-cell line from the peripheral blood of a patient with Sézary syndrome, which expresses a mature helper T-cell phenotype and contains...
Topics
- Aged
- Antibodies, Monoclonal
- Antigens, CD
- Antigens, Surface
- CD4 Antigens
- Cell Line
- Culture Techniques
- DNA Probes
- DNA Replication
- DNA, Neoplasm
- Female