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Article

Replicative aging of human articular chondrocytes during ex vivo expansion

1 Nov 2002

Abstract excerpt

OBJECTIVE: To investigate the contribution of clinical ex vivo expansion protocols to replicative aging of human chondrocytes. METHODS: Primary human chondrocytes were cultured as monolayers after isolation from 7 articular cartilage specimens. Cells were passaged corresponding to 12-19 cell population doublings (cpd). Aliquots of the cells were collected from each passage and analyzed for telomere length and...

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PMID: 12428231
DOI: 10.1002/art.10626

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