Article
Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I.
Blood - 1 May 1997
Richardson J H, Höllsberg P, Windhagen A, Child L A, Hafler D A, Lever A M
Abstract excerpt
Human T-cell leukemia virus type I (HTLV-I)-infected T cells expanded in vitro by single-cell cloning provide a unique system for investigating virus-cell interactions in nonimmortalized T cells. By analysis of clones generated randomly from the blood of virus carriers, we confirm that CD4 T cell...
Topics
- Blotting, Southern
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Viral
- Clone Cells
- Cytokines
- DNA Primers
- Gene Products, gag
- Gene Rearrangement, T-Lymphocyte
- Human T-lymphotropic virus 1
- Humans
- Phenotype
- Polymerase Chain Reaction
- RNA, Messenger
- T-Lymphocytes
- Transcription, Genetic