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Article

Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?

Mechanisms of ageing and development - 15 Sept 1995

Adibzadeh M, Pohla H, Rehbein A, Pawelec G

Abstract excerpt

Human monoclonal T lymphocyte populations maintained in long-term culture by intermittent reactivation via the antigen receptor and supplied with exogenous interleukin 2 manifest finite proliferative lifespans. T lymphocytes cloned from mature peripheral T cells of adult donors were constantly lost from the time point of their first isolation up to an estimated maximum of 80 population doublings (PD) for the...

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PMID: 8583835
DOI: 10.1016/0047-6374(95)01625-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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