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Persistence of high‐replicative capacity in cultured fibroblasts from nonagenarians

15 Nov 2006

Abstract excerpt

Earlier studies on human fibroblast cultures have demonstrated an inverse relationship between the total number of population doublings (PDs) and donor age. As more recent studies were unable to replicate these findings, we set out to analyze growth characteristics of fibroblast cultures from nonagenarians who represent the extreme of human lifespan. Therefore, we obtained skin biopsies from 68 participants of...

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PMID: 17266674
DOI: 10.1111/j.1474-9726.2006.00263.x

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