Article
Negative regulation of human c-fos expression by the retinoblastoma gene product.
Nature - 16 Aug 1990
Robbins P D, Horowitz J M, Mulligan R C
Abstract excerpt
Inactivation of the retinoblastoma susceptibility gene (RB-1) has been associated with the aetiology of many types of human cancers, leading to the classification of RB-1 as an anti-oncogene or tumour suppressor gene. Given that the protein product of RB-1 (Rb) has a nuclear localization and DNA-binding activity in vitro, it is possible that Rb regulates transcription of certain genes. The promoter of the c-fos...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Chloramphenicol O-Acetyltransferase
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Humans
- Mice
- Molecular Sequence Data
- Mutation