Article
[Role of the TCF phosphorylation state and the chromatin structure in the negative transcription regulation of the c-fos proto-oncogene in E1A + c-Ha-ras transformed cells].
Molekuliarnaia biologiia - 1 Jan 2000
Abramova M V, Kukushkin A N, Pospelova T V, Svetlikova S B, Pospelov V A
Abstract excerpt
As compared with normal rat embryo fibroblasts (REF), c-fos transcription is suppressed in REF transformed with the E1A and cHa-ras complementing oncogenes. Negative regulation of the fos promoter is due to the serum-responsive element (SRE) constantly bound with the serum response factor (SRF) and with the ternary complex factor (TCF), which form the SRF/SRF/TCF complex. Possible mechanisms of the c-fos...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.