Article
Combination of drugs and drug-resistant reverse transcriptase results in a multiplicative increase of human immunodeficiency virus type 1 mutant frequencies.
Journal of virology - 1 Sept 2002
Mansky Louis M, Pearl Dennis K, Gajary Lisa C
Abstract excerpt
Replication of drug-resistant human immunodeficiency virus type 1 (HIV-1) in the presence of drug can lead to the failure of antiretroviral drug treatment. Drug failure is associated with the accumulation of drug resistance mutations. Previous studies have shown that 3'-azido-3'-deoxythymidine (AZT), (-)2',3'-dideoxy-3'-thiacytidine (3TC), and AZT-resistant HIV-1 reverse transcriptase (RT) can increase the virus...
Topics
- Animals
- Anti-HIV Agents
- COS Cells
- Dose-Response Relationship, Drug
- Drug Resistance, Viral
- Genetic Vectors
- HIV Reverse Transcriptase
- HIV-1
- HeLa Cells
- Humans
- Hydroxyurea
- Lamivudine
- Mutation
- Reverse Transcriptase Inhibitors