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Article

AZT-resistant foamy virus.

Virology - 5 Jan 2008

Kretzschmar Benedikt, Nowrouzi Ali, Hartl Maximilian J, Gärtner Kathleen, Wiktorowicz Tatiana, Herchenröder Ottmar, Kanzler Sylvia, Rudolph Wolfram, Mergia Ayalew, Wöhrl Birgitta, Rethwilm Axel

Abstract excerpt

Azidothymidine (AZT) is a reverse transcriptase (RT) inhibitor that efficiently blocks the replication of spumaretroviruses or foamy viruses (FVs). To more precisely elucidate the mechanism of action of the FV RT enzyme, we generated an AZT-resistant FV in cell culture. Biologically resistant virus was obtained for simian foamy virus from macaque (SFVmac), which was insensitive to AZT concentrations of 1 mM, but...

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Identifiers

PMID: 17904181
DOI: 10.1016/j.virol.2007.08.025
PMCID: PMC2276251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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