Article
Rapid phenotypic reversion of zidovudine-resistant feline immunodeficiency virus without loss of drug-resistant reverse transcriptase.
Journal of virology - 1 Feb 1994
Remington K M, Zhu Y Q, Phillips T R, North T W
Abstract excerpt
We have selected and plaque purified zidovudine (3'-azido-3'-deoxythymidine [AZT])-resistant mutants from an infectious molecular clone of feline immunodeficiency virus (FIV). The patterns of cross-resistance and drug susceptibilities of these mutants were similar to those of the AZT-resistant FI...
Topics
- Animals
- Base Sequence
- Cats
- Cells, Cultured
- Cloning, Molecular
- Drug Resistance, Microbial
- Immunodeficiency Virus, Feline
- Molecular Sequence Data
- Phenotype
- Point Mutation
- RNA-Directed DNA Polymerase
- Selection, Genetic
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
- Viral Plaque Assay
- Zidovudine