Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver.

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Article

Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver.

The Journal of biological chemistry - 8 Jul 1994

Chiron M F, Fryling C M, FitzGerald D J

Abstract excerpt

Pseudomonas exotoxin (PE) is cleaved within mammalian cells between Arg279 and Gly280 to generate an enzymatically active COOH-terminal fragment of 37 kDa which translocates to the cytosol and ADP-ribosylates elongation factor 2. A protease, with toxin cleaving activity, was prepared from beef li...

Topics

ADP Ribose Transferases
Animals
Bacterial Toxins
Cattle
Cell Line
Diphtheria Toxin
Exotoxins
Furin
Hydrogen-Ion Concentration
Kinetics
Liver
Mice
Mutation
Subtilisins
Virulence Factors
Pseudomonas aeruginosa Exotoxin A

Source

Open in PubMed

Identifiers

PMID: 8027078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8027078-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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