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Article

Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity.

Journal of molecular biology - 7 Dec 2001

Wedekind J E, Trame C B, Dorywalska M, Koehl P, Raschke T M, McKee M, FitzGerald D, Collier R J, McKay D B

Abstract excerpt

Exotoxin A of Pseudomonas aeruginosa asserts its cellular toxicity through ADP-ribosylation of translation elongation factor 2, predicated on binding to specific cell surface receptors and intracellular trafficking via a complex pathway that ultimately results in translocation of an enzymatic activity into the cytoplasm. In early work, the crystallographic structure of exotoxin A was determined to 3.0 A...

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Identifiers

PMID: 11734000
DOI: 10.1006/jmbi.2001.5195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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