Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation.

Biochemistry - 23 Jul 1991

Siegall C B, Ogata M, Pastan I, FitzGerald D J

Abstract excerpt

Pseudomonas exotoxin (PE) contains 613 amino acids that are arranged into 3 structural domains. PE exerts its cell-killing effects in a series of steps initiated by binding to the cell surface and internalization into endocytic vesicles. The toxin is then cleaved within domain II near arginine-279, generating a C-terminal 37-kDa fragment that is translocated into the cytosol where it ADP-ribosylates elongation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Chimera
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Source

Identifiers

PMID: 1906738
DOI: 10.1021/bi00243a016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation.PMID 1906738Read ↗

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.Semantic proximity Read ↗

Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.Semantic proximity Read ↗

Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity.Semantic proximity Read ↗

Mutagenesis of Pseudomonas exotoxin in identification of sequences responsible for the animal toxicity.Semantic proximity Read ↗

Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.Semantic proximity Read ↗

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.Semantic proximity Read ↗

A leucine-rich motif targets Pseudomonas aeruginosa ExoS within mammalian cells.Semantic proximity Read ↗

Structure-function analysis of exotoxin A proteins with mutations at histidine 426.Semantic proximity Read ↗

Influence of deletions within domain II of exotoxin A on its extracellular secretion from Pseudomonas aeruginosa.Semantic proximity Read ↗

An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin.Semantic proximity Read ↗

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.Semantic proximity Read ↗

Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.