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Article

Differential expression of activation markers during tolerance induction by superantigens in T-cell receptor (beta-chain) transgenic mice.

Cellular immunology - 1 Jul 1994

Perkins D L, Listman J A, Wang Y, Ho S S, Finn P W, Rimm I J

Abstract excerpt

To investigate the process of tolerance induction we have developed an in vivo model using TCR beta-chain transgenic mice tolerized with the superantigen staphylococcal enterotoxin B. We have previously demonstrated that tolerized peripheral T cells were anergic when stimulated in vitro with immunogenic peptides, superantigens, mitogens, and immobilized anti-TCR mAb. However, the development of anergy is preceded...

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Identifiers

PMID: 8025950
DOI: 10.1006/cimm.1994.1177

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