Article
Mechanisms of peripheral immune tolerance: conversion of the immune to the unresponsive phenotype.
Immunologic research - 1 Jan 2003
Saouaf Sandra J, Brennan Patrick J, Shen Yuan, Greene Mark I
Abstract excerpt
Our studies on the immune response to foreign antigens are reviewed as they relate to the mechanisms of peripheral immune tolerance. The activation of suppressor T cells by distinct modes of antigen presentation is discussed. Through the use of mice expressing transgenic T-cell receptors specific for foreign antigens, we have concluded that the separable mechanisms of anergy and active suppression by CD25+ T...
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