Article
Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994
McCormack J E, Kappler J, Marrack P
Abstract excerpt
The T-cell response to pigeon cytochrome c peptide, residues 88-104 (pcytC), in B10.BR mice is mediated largely by cells bearing both V beta 3 and V alpha 11 variable regions of the T-cell antigen receptor. These cells are, therefore, reactive with the superantigen staphylococcal enterotoxin A (SEA). Recent reports have shown that in vivo exposure to superantigen can lead to deletion of superantigen-reactive T...
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