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Article

Induction of Immunosuppressive CD8+CD25+FOXP3+ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2018

Lee Juyeun, Park Nogi, Park Joo Youn, Kaplan Barbara L F, Pruett Stephen B, Park Juw Won, Park Yong Ho, Seo Keun Seok

Abstract excerpt

Superantigens (SAgs) produced by Staphylococcus aureus at high concentrations induce proliferation of T cells bearing specific TCR Vβ sequences and massive cytokinemia that cause toxic shock syndrome. However, the biological relevance of SAgs produced at very low concentrations during asymptomatic colonization or chronic infections is not understood. In this study, we demonstrate that suboptimal stimulation of...

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Source

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Identifiers

PMID: 29237775
DOI: 10.4049/jimmunol.1602109
PMCID: PMC5757107

Genes

FOXP3
CD28
CD4
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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