Article
Newly generated thymocytes are not refractory to deletion when the alpha/beta component of the T cell receptor is engaged by the superantigen staphylococcal enterotoxin B.
European journal of immunology - 1 Nov 1990
Jenkinson E J, Kingston R, Owen J J
Abstract excerpt
It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selecti...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- DNA
- Enterotoxins
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- Staphylococcus aureus
- T-Lymphocytes