Article
Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rats.
Japanese journal of cancer research : Gann - 1 Dec 1993
Yamaguchi S, Hakoi K, Ozaki K, Kato T, Tiwawech D, Nagao S, Takahashi H, Matsumoto K, Tsuda H
Abstract excerpt
Preneoplastic and neoplastic liver cell lesions, induced by EHEN (N-ethyl-N-hydroxyethylnitrosamine) in rats, were investigated to establish the numbers of simultaneously expressed altered enzyme phenotypes within the lesion cells. The lesions were divided into 5 classes on the basis of altered e...
Topics
- Adenosine Triphosphatases
- Animals
- Biomarkers
- Bromodeoxyuridine
- Carcinoma, Hepatocellular
- Cell Division
- Diethylnitrosamine
- Glucose-6-Phosphatase
- Glucosephosphate Dehydrogenase
- Glutathione Transferase
- Liver Neoplasms
- Male
- Neoplasm Staging