Article
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Carcinogenesis - 1 May 1994
Devereux T R, White C M, Sills R C, Bucher J R, Maronpot R R, Anderson M W
Abstract excerpt
Oxazepam has been the subject of recent toxicological and carcinogenesis studies because it is a commonly prescribed tranquilizer and has been shown to cause tumors in rodents. In this study, male and female B6C3F1 mice received 0, 125, 2500 or 5000 p.p.m. oxazepam in the diet for up to 2 years....
Topics
- Adenoma
- Animals
- Codon
- Diet
- Dose-Response Relationship, Drug
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Hepatoblastoma
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred Strains
- Mutation
- Oxazepam