Article
Inhibition of p21ras activation blocks proliferation but not differentiation of interleukin-3-dependent myeloid cells.
The Journal of biological chemistry - 7 Oct 1994
Okuda K, Ernst T J, Griffin J D
Abstract excerpt
Interleukin-3 (IL-3) induces proliferation of immature myeloid cells and mast cells and prevents programmed cell death (apoptosis) in vitro. These activities are exerted through binding of IL-3 to specific, high affinity receptors that then initiate a series of intracellular signaling events. Amo...
Topics
- Cell Cycle
- Cell Differentiation
- Cell Division
- Cell Line
- Dexamethasone
- Granulocyte Colony-Stimulating Factor
- Humans
- Interleukin-3
- Mutation
- Proto-Oncogene Proteins p21(ras)