Article
Mutations of the p53 gene in male breast cancer.
Cancer - 1 May 1995
Anelli A, Anelli T F, Youngson B, Rosen P P, Borgen P I
Abstract excerpt
BACKGROUND: Cancer of the male breast (MBC) is rare, accounting for less than 1% of cancer in males and representing less than 1% of all breast cancers. Reports of abnormalities in the expression of the tumor suppressor gene p53 in MBC have been few. METHODS: To assess the expression and mutations of the p53 gene, 35 patients with 36 MBC (one patient with bilateral breast carcinoma) were examined using...
Topics
- Age Factors
- Aged
- Breast Neoplasms, Male
- Carcinoma, Ductal, Breast
- Disease-Free Survival
- Exons
- Follow-Up Studies
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Immunohistochemistry
- Incidence