Article
Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant.
Journal of lipid research - 1 Mar 1994
Fazio S, Horie Y, Simonet W S, Weisgraber K H, Taylor J M, Rall S C
Abstract excerpt
Transgenic mouse lines were produced that expressed low levels of a receptor-binding-defective variant of human apolipoprotein (apo) E, apoE(Arg112, Cys142). In transgenic mice, the human apoE was produced only by the kidney, whereas endogenous mouse apoE was produced mainly by the liver. The pla...
Topics
- Animals
- Apolipoproteins E
- Blotting, Southern
- Blotting, Western
- Cholesterol
- Gene Expression
- Humans
- Immunoblotting
- Lipoproteins
- Lipoproteins, HDL
- Mice
- Mice, Inbred ICR
- Mice, Transgenic
- Mutation
- Particle Size
- Triglycerides