Article
Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice.
Clinical chemistry and laboratory medicine - 1 Jan 2005
Wouters Kristiaan, Shiri-Sverdlov Ronit, van Gorp Patrick J, van Bilsen Marc, Hofker Marten H
Abstract excerpt
Hyperlipidemia is the most important risk factor for atherosclerosis, which is the major cause of cardiovascular disease. The etiology of hyperlipidemia and atherosclerosis is complex and governed by multiple interacting genes. However, mutations in two genes have been shown to be directly involved, i.e., the low-density lipoprotein receptor (LDLR) and apolipoprotein E (ApoE). Genetically modified mouse models...
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