Article
Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.
The Journal of clinical investigation - 1 Sept 1993
Fazio S, Lee Y L, Ji Z S, Rall S C
Abstract excerpt
Transgenic mice were prepared that expressed a dysfunctional apo E variant, apo E (Arg-112, Cys-142), which is associated with dominant inheritance of type III hyperlipoproteinemia (type III HLP) in humans. Among eight founder mice, plasma apo E (Arg-112, Cys-142) levels varied 100-fold and direc...
Topics
- Animals
- Apolipoproteins E
- Female
- Gene Expression
- Hyperlipoproteinemia Type III
- Lipoproteins, VLDL
- Male
- Mice
- Mice, Transgenic
- Phenotype
- RNA, Messenger