Article
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II.
The Journal of biological chemistry - 22 Mar 1996
Marzal-Casacuberta A, Blanco-Vaca F, Ishida B Y, Julve-Gil J, Shen J, Calvet-Márquez S, González-Sastre F, Chan L
Abstract excerpt
The concentration of high density lipoproteins (HDL) is inversely related to the risk of atherosclerosis. The two major protein components of HDL are apolipoprotein (apo) A-I and apoA-II. To study the role of apoA-II in lipoprotein metabolism and atherosclerosis, we have developed three lines of C57BL/6 transgenic mice expressing human apoA-II (lines 25.3, 21.5, and 11.1). Northern blot experiments showed that...
Topics
- Animals
- Apolipoprotein A-II
- Cholesterol
- Cholesterol, Dietary
- Dietary Fats
- Humans
- Lipoproteins, HDL
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic