Article
Decreased susceptibility to diet-induced atherosclerosis in human apolipoprotein A-II transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2000
Tailleux A, Bouly M, Luc G, Castro G, Caillaud J M, Hennuyer N, Poulain P, Fruchart J C, Duverger N, Fiévet C
Abstract excerpt
Studies performed in vivo have been controversial regarding the implication of human apolipoprotein (apo)A-II in the atherogenic process. Expression of human apoA-II in transgenic mice fed a chow diet leads to (1) a bimodal distribution of high density lipoprotein (HDL) size as in humans, (2) a reduction in total cholesterol concentration that is mainly due to a reduction in non-HDL cholesterol level, and (3) a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
