Article
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
The Journal of biological chemistry - 15 Nov 1996
Huang Y, Schwendner S W, Rall S C, Mahley R W
Abstract excerpt
Transgenic mice were produced that expressed different plasma levels (3-60 mg/dl) of human apolipoprotein (apo) E2(Arg158 --> Cys), which is associated with the recessive form of human type III hyperlipoproteinemia (HLP). In transgenic mice fed a normal chow diet, low levels of apoE2 (<10 mg/dl)...
Topics
- Animals
- Apolipoprotein E2
- Apolipoproteins E
- Heterozygote
- Humans
- Hyperlipidemias
- Lipids
- Male
- Mice
- Mice, Inbred ICR
- Mice, Transgenic
- Phenotype