Article
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.
The Journal of biological chemistry - 5 Sept 1997
Huang Y, Schwendner S W, Rall S C, Sanan D A, Mahley R W
Abstract excerpt
Transgenic rabbits were produced that expressed high plasma levels (30-70 mg/dl) of human apolipoprotein (apo) E2(Cys-158), an apoE variant associated with the human genetic disorder type III hyperlipoproteinemia (HLP). Male transgenic rabbits fed normal chow had up to 8-fold (289 +/- 148 mg/dl)...
Topics
- Animals
- Animals, Genetically Modified
- Apolipoprotein E2
- Apolipoproteins E
- Arteriosclerosis
- Estrogens
- Female
- Hyperlipoproteinemias
- Lipids
- Lipolysis
- Lipoproteins, VLDL
- Male
- Phenotype
- Rabbits