Article
Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis.
The Journal of biological chemistry - 18 Jul 1997
Sullivan P M, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick R L, Quarfordt S H, Maeda N
Abstract excerpt
Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipoprotein receptor, and this interaction is important for maintaining cholesterol and triglyceride homeostasis. We have used a gene replacement strategy to generate mice that express the human apoE3 i...
Topics
- Alleles
- Animals
- Apolipoprotein E3
- Apolipoproteins E
- Arteriosclerosis
- Cholesterol
- Cholesterol, HDL
- Diet, Atherogenic
- Female
- Homozygote
- Humans
- Hypercholesterolemia
- Male
- Mice
- Mice, Transgenic