Article
Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis.
The Journal of biological chemistry - 18 Jul 1997
Sullivan P M, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick R L, Quarfordt S H, Maeda N
Abstract excerpt
Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipoprotein receptor, and this interaction is important for maintaining cholesterol and triglyceride homeostasis. We have used a gene replacement strategy to generate mice that express the human apoE3 isoform in place of the mouse protein. The levels of apoE mRNA in various tissues are virtually the same in the human...
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