Article
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Huang Y, Rall S C, Mahley R W
Abstract excerpt
Several factors are hypothesized to precipitate or exacerbate type III hyperlipoproteinemia (HLP) in humans. Among such factors are those that directly overload remnant lipoprotein production or disrupt removal pathways, including an increased ratio of apolipoprotein (apo) E2 to normal apoE, over...
Topics
- Animals
- Apolipoprotein E2
- Apolipoproteins B
- Apolipoproteins E
- Cholesterol
- Crosses, Genetic
- Disease Models, Animal
- Epistasis, Genetic
- Female
- Genotype
- Humans
- Hyperlipoproteinemia Type III
- Lipids
- Male
- Mice
- Mice, Inbred ICR
- Mice, Knockout
- Mice, Transgenic