Article
Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Nov 1994
Fazio S, Sanan D A, Lee Y L, Ji Z S, Mahley R W, Rall S C
Abstract excerpt
Transgenic mice expressing apolipoprotein (apo) E(Cys 142), a human defective variant of apo E, have elevated levels of plasma cholesterol, triglycerides, and very-low-density lipoproteins (VLDL); beta-VLDL, the biochemical hallmark of the human genetic disease type III hyperlipoproteinemia (HLP), is also present in these mice. This study was designed to determine whether these type III HLP mice have an increased...
Topics
- Animals
- Aorta
- Apolipoproteins E
- Arteriosclerosis
- Cholesterol
- Cholesterol, Dietary
- Diet
- Genetic Predisposition to Disease
- Hybridization, Genetic
- Male
- Mice