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Article

Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor.

Biochimica et biophysica acta - 30 Aug 2004

Knouff Christopher, Briand Olivier, Lestavel Sophie, Clavey Veronique, Altenburg Michael, Maeda Nobuyo

Abstract excerpt

Differences in affinity of human apolipoprotein E (apoE) isoforms for the low density lipoprotein receptor (LDLR) are thought to result in the differences in lipid metabolism observed in humans with different APOE genotypes. Mice expressing three common human apoE isoforms, E2, E3, and E4, in place of endogenous mouse apoE were used to investigate the relative roles of apoE isoforms in LDLR- and non-LDLR-mediated...

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Source

Identifiers

PMID: 15450205
DOI: 10.1016/j.bbalip.2004.03.004

Genes

LDLR
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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