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Article

Tumor-suppressor p53 and the cell cycle.

Current opinion in genetics & development - 1 Feb 1993

Perry M E, Levine A J

Abstract excerpt

The p53 tumor suppressor is a transcription factor that can activate the expression of some genes and repress the transcription of others. The protein appears to be dispensable for normal murine development, although mice lacking p53 develop tumors at an early age and their fibroblasts are genetically unstable in culture. Human and murine cells lacking wild-type p53 loose the ability to arrest in the G1 phase of...

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Source

Identifiers

PMID: 8453275
DOI: 10.1016/s0959-437x(05)80340-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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