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Article

Mutations in the conserved regions of p53 are infrequent in betel-associated oral cancers from Papua New Guinea.

Cancer research - 1 Jul 1994

Thomas S, Brennan J, Martel G, Frazer I, Montesano R, Sidransky D, Hollstein M

Abstract excerpt

Seventy-five % of the world's oral cancers arise in developing countries. In high incidence areas of Southeast Asia such as Papua New Guinea (PNG) the major region-specific risk exposure is betel quid chewing. While it has been shown that p53 gene mutations in the conserved midregion (exons 5-9) are a common feature of oral cancers in the developed world, there is no information on this type of genetic lesion in...

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PMID: 8012986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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