Article
Mutations in the conserved regions of p53 are infrequent in betel-associated oral cancers from Papua New Guinea.
Cancer research - 1 Jul 1994
Thomas S, Brennan J, Martel G, Frazer I, Montesano R, Sidransky D, Hollstein M
Abstract excerpt
Seventy-five % of the world's oral cancers arise in developing countries. In high incidence areas of Southeast Asia such as Papua New Guinea (PNG) the major region-specific risk exposure is betel quid chewing. While it has been shown that p53 gene mutations in the conserved midregion (exons 5-9)...
Topics
- Adult
- Aged
- Aged, 80 and over
- Areca
- Baltimore
- Carcinoma, Squamous Cell
- Conserved Sequence
- Exons
- Female
- Genes, p53
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mouth Neoplasms
- Mutation
- Papua New Guinea
- Plants, Medicinal