Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers.

doi:10.1002/(SICI)1097-0215(19961115)68:4<420::AID-IJC3>3.0.CO;2-2

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Article

Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers.

International journal of cancer - 15 Nov 1996

Heinzel P A, Balaram P, Bernard H U

Abstract excerpt

India has one of the world's highest incidences of oral cancer. It is believed that the widespread habit of betel quid chewing is an important risk factor as it exposes the oral mucosa to known carcinogens. It also induces physical abrasions, which may create mitogenic environments during wound h...

Topics

Areca
Carrier Proteins
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Genes, Tumor Suppressor
Genes, p53
Humans
Mouth Neoplasms
Mutation
Plants, Medicinal
Polymorphism, Genetic

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