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Article

Pattern of p53 gene mutations in breast cancers of women of the midwestern United States.

Journal of the National Cancer Institute - 19 Feb 1992

Sommer S S, Cunningham J, McGovern R M, Saitoh S, Schroeder J J, Wold L E, Kovach J S

Abstract excerpt

BACKGROUND: Mutation in the p53 gene is the most common genetic lesion in human cancers. The pattern of mutation in the p53 gene differs among cancers and may be a useful epidemiological tool for identification of factors contributing to carcinogenesis. PURPOSE: Our purpose was to determine if the pattern of p53 mutation in breast carcinomas in our population of women residing in the midwestern region of the...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Breast Neoplasms
DNA, Neoplasm
Female
Gene Amplification
Genes, p53
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Tumor Suppressor Protein p53

United States

Source

Identifiers

PMID: 1734086
DOI: 10.1093/jnci/84.4.246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1734086-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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