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Article

Infrequent p53 mutations in patients with areca quid chewing‐associated oral squamous cell carcinomas in Taiwan

1 May 1999

Abstract excerpt

Mutations in the conserved regions (exons 5-9) of the p53 gene were investigated in 37 untreated human primary oral squamous cell carcinomas (SCCs) using polymerase chain reaction-single strand conformation polymorphism and DNA sequencing analyses. P53 mutations were detected in 2 of 37 (5.4%) oral SCC cases. One tumor sample (case 23) showed a mis-sense point mutation at codon 177, changing CCC to CTC, which...

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PMID: 10226945
DOI: 10.1111/j.1600-0714.1999.tb02028.x

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