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Article

APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia.

Experimental and molecular pathology - 1 Dec 2004

Kapitanović Sanja, Cacev Tamara, Radosević Senka, Spaventi Sime, Spaventi Radan, Pavelić Kresimir

Abstract excerpt

Colorectal carcinomas are characterized by multiple genetic aberrations that occur during tumorigenesis. Several tumor suppressor genes associated with colorectal carcinoma have been identified: MCC, APC, p53, nm23-H1, DCC, DPC4. We examined 73 cases of sporadic human colon cancer and corresponding normal tissue samples to evaluate the loss of heterozygosity (LOH) at the APC gene loci. The purpose of this study...

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Source

Identifiers

PMID: 15507235
DOI: 10.1016/j.yexmp.2004.06.001

Genes

APC
DCC
MCC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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