Article
Development of electrical myotonia in the ADR mouse: role of chloride conductance in myotubes and neonatal animals.
Neuromuscular disorders : NMD - 1 Jul 1993
Wischmeyer E, Nolte E, Klocke R, Jockusch H, Brinkmeier H
Abstract excerpt
In the ADR mouse, the homozygous condition of the autosomal mutation adr, "arrested development of righting response", leads to the symptoms of myotonia. The adr mutation is caused by an insertion of a retroposon into a gene for a chloride channel (adr = Clc-1) that is expressed in adults, but only at very low levels in neonate rodent muscle. In the present study, we investigated the earliest stages of the ADR...
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