Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myotonic ADR-MDX mutant mice show less severe muscular dystrophy than MDX mice.

Neuromuscular disorders : NMD - 1 Dec 1998

Krämer R, Lochmüller H, Abicht A, Rüdel R, Brinkmeier H

Abstract excerpt

In Duchenne muscular dystrophy (DMD) and its murine model, the dystrophic mouse (MDX), the skeletal musculature lacks dystrophin. The presumed function of this cytoskeletal protein is to protect the sarcolemma against mechanical stress during muscle activity. To test this hypothesis in vivo, we bred a double mutant mouse that combines two genetic defects: the dystrophin-deficiency of the MDX mouse and the Cl-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Creatine Kinase
Share to Diaphragm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred mdx

Share to Mice, Mutant Strains

Share to Muscular Dystrophy, Animal

Share to Myotonia

Share to Organ Size

Source

Identifiers

PMID: 10093060
DOI: 10.1016/s0960-8966(98)00078-9

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myotonic ADR-MDX mutant mice show less severe muscular dystrophy than MDX mice.PMID 10093060Read ↗

Duchenne muscular dystrophy: pathogenesis and promising therapies.Semantic proximity Read ↗

Current Translational Research and Murine Models For Duchenne Muscular DystrophySemantic proximity Read ↗

Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosisSemantic proximity Read ↗

Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation.Semantic proximity Read ↗

Activation of the MEF2 transcription factor in skeletal muscles from myotonic mice.Semantic proximity Read ↗

Functional and structural pathologies in skeletal muscle of a rat model of Duchenne muscular dystrophySemantic proximity Read ↗

A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic Dmd deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathySemantic proximity Read ↗

Cardiovascular phenotype of the Dmdmdx rat - a suitable animal model for Duchenne muscular dystrophy.Semantic proximity Read ↗

Transcriptomic analysis of mdx mouse muscles reveals a signature of early human Duchenne muscular dystrophySemantic proximity Read ↗

Functional characteristics of dystrophic skeletal muscle: insights from animal modelsSemantic proximity Read ↗

Age-Dependent Echocardiographic and Pathologic Findings in a Rat Model with Duchenne Muscular Dystrophy Generated by CRISPR/Cas9 Genome EditingSemantic proximity Read ↗

Humanization of the mdx Mouse Phenotype for Duchenne Muscular Dystrophy Modeling: A Metabolic Perspective.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.