Article
K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.
Gastroenterology - 1 Apr 1997
Anker P, Lefort F, Vasioukhin V, Lyautey J, Lederrey C, Chen X Q, Stroun M, Mulcahy H E, Farthing M J
Abstract excerpt
BACKGROUND & AIMS: Circulating DNA can be isolated from the plasma of healthy subjects and from patients with cancer. The aim of this study was to detect K-ras mutations in DNA extracted from the plasma of patients with colorectal cancer. METHODS: Tumor and plasma DNA were extracted from 14 patie...
Topics
- Adult
- Aged
- Bacteriophages
- Base Sequence
- Cloning, Molecular
- Colorectal Neoplasms
- DNA, Neoplasm
- Female
- Genes, ras
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length