Article
K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.
Gastroenterology - 1 Apr 1997
Anker P, Lefort F, Vasioukhin V, Lyautey J, Lederrey C, Chen X Q, Stroun M, Mulcahy H E, Farthing M J
Abstract excerpt
BACKGROUND & AIMS: Circulating DNA can be isolated from the plasma of healthy subjects and from patients with cancer. The aim of this study was to detect K-ras mutations in DNA extracted from the plasma of patients with colorectal cancer. METHODS: Tumor and plasma DNA were extracted from 14 patients with colorectal cancer (stages A-D), and K-ras alterations were detected using a polymerase chain reaction assay...
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