Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.

doi:10.1373/clinchem.2006.078188

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Article

Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.

Clinical chemistry - 1 Apr 2007

Haug Ulrike, Hillebrand Timo, Bendzko Peter, Löw Michael, Rothenbacher Dietrich, Stegmaier Christa, Brenner Hermann

Abstract excerpt

BACKGROUND: Testing for mutant K-ras in stool has been proposed for the detection of pancreatic and colorectal cancer (CRC). Different analytical techniques have been developed, but studies of this biomarker in the general population are lacking. We investigated the prevalence and potential deter...

Topics

Adenoma
Aged
Alleles
Cohort Studies
Colonoscopy
Colorectal Neoplasms
DNA
Feces
Female
Genes, ras
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Nucleic Acid Hybridization

Pancreatic Elastase

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 17317884
DOI: 10.1373/clinchem.2006.078188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17317884-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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