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Article

Critical role for constitutive type I interferon signaling in the prevention of cellular transformation

15 Dec 2008

Abstract excerpt

Interferons-alpha/beta, which are produced upon viral infection, are key soluble factors for the establishment of an antiviral state, but are also produced at low levels in the absence of infection. Herein, we demonstrate that a weak signal by these constitutively produced IFN-alpha/beta show a preventive role in cellular transformation. Ifnar1-deficient (Ifnar1(-/-)) MEF, which are devoid of IFN-alpha/beta...

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PMID: 19076978
DOI: 10.1111/j.1349-7006.2008.01051.x

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