Article
Involvement of the IRF-1 transcription factor in antiviral responses to interferons.
Science (New York, N.Y.) - 24 Jun 1994
Kimura T, Nakayama K, Penninger J, Kitagawa M, Harada H, Matsuyama T, Tanaka N, Kamijo R, Vilcek J, Mak T W
Abstract excerpt
The mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-alpha an...
Topics
- Animals
- Cardiovirus Infections
- Cells, Cultured
- DNA-Binding Proteins
- Encephalomyocarditis virus
- Gene Expression Regulation
- Interferon Regulatory Factor-1
- Interferon-alpha
- Interferon-gamma
- Mice
- Mutation
- Phosphoproteins
- Simplexvirus
- Transcription Factors
- Vesicular stomatitis Indiana virus