Article
The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86.
European journal of immunology - 1 Feb 1993
Demotz S, Barbey C, Corradin G, Amoroso A, Lanzavecchia A
Abstract excerpt
The response to tetanus toxoid (TT) was studied in immune donors that carry two alleles of DR5 that differ only at DR beta residue 86: DRB1*1101 (G86, abbreviated 1101) and DRB1*1104 (V86, abbreviated 1104). A large number of TT-specific T cell clones was isolated and the epitopes recognized in a...
Topics
- Alleles
- Amino Acid Sequence
- Antigen-Presenting Cells
- Base Sequence
- Cell Line
- Cells, Cultured
- Epitopes
- HLA-DR1 Antigen
- Humans
- Lymphocyte Activation
- Molecular Sequence Data
- Oligonucleotide Probes
- Peptides
- Polymorphism, Genetic
- Protein Binding
- T-Lymphocytes
- Tetanus Toxoid