Article
The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86.
European journal of immunology - 1 Feb 1993
Demotz S, Barbey C, Corradin G, Amoroso A, Lanzavecchia A
Abstract excerpt
The response to tetanus toxoid (TT) was studied in immune donors that carry two alleles of DR5 that differ only at DR beta residue 86: DRB1*1101 (G86, abbreviated 1101) and DRB1*1104 (V86, abbreviated 1104). A large number of TT-specific T cell clones was isolated and the epitopes recognized in association with 1101 and 1104 were mapped. We found that two epitopes (p2 and p32) can be recognized in association...
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