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Article

Functional analysis of two tetanus toxin universal T cell epitopes in their interaction with DR1101 and DR1104 alleles.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1994

Valmori D, Sabbatini A, Lanzavecchia A, Corradin G, Matricardi P M

Abstract excerpt

In this study we have investigated the interaction between two DR11 alleles (DB*1101 and DB*1104) and two previously described tetanus toxin (tt) universal T cell epitopes P2(tt830-843) and P30(tt947-967) by means of a functional cytotoxic competition assay. Both truncation analysis and single alanine substitution analysis were performed. In addition, the capacity of truncated and single alanine substituted...

Topics

Alleles
Amino Acid Sequence
Epitopes
HLA-DR Antigens
HLA-DR Serological Subtypes
Humans
Molecular Sequence Data
Peptide Fragments
Receptors, Antigen, T-Cell
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Tetanus Toxin

Source

Identifiers

PMID: 7511633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7511633-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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