Article
Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants.
Nature - 1 Jan 2000
Cairns J S, Curtsinger J M, Dahl C A, Freeman S, Alter B J, Bach F H
Abstract excerpt
HLA class II molecules are a highly polymorphic family of dimeric cell-surface proteins primarily involved in regulating T-cell responses to extrinsic antigens. To define regions of class II molecules involved in T-cell recognition, we have now compared sequences of three HLA DR beta cDNA clones obtained from cells that all express the same serologically defined determinants but differ in terms of...
Topics
- Alleles
- Base Sequence
- Cloning, Molecular
- DNA
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Humans
- Polymorphism, Genetic
- T-Lymphocytes