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Article

Individual effects of the DR11-variable beta-chain residues 67, 71, and 86 upon DR(alpha,beta 1*1101)-restricted, peptide-specific T cell proliferation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1994

McKinney J S, Fu X T, Swearingen C, Klohe E, Karr R W

Abstract excerpt

The four members of the HLA-DR11 family of class II molecules vary only by three or fewer amino acids via dimorphisms among DR beta-chain residues 67, 71, and 86. However, they differ markedly in their abilities to induce proliferation of DR(alpha,beta 1*1101)-restricted, peptide-specific T cell clones. To dissect which DR11-variable residues, individually and in combination, mediate these functional differences,...

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PMID: 7989758

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