Article
Individual effects of the DR11-variable beta-chain residues 67, 71, and 86 upon DR(alpha,beta 1*1101)-restricted, peptide-specific T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1994
McKinney J S, Fu X T, Swearingen C, Klohe E, Karr R W
Abstract excerpt
The four members of the HLA-DR11 family of class II molecules vary only by three or fewer amino acids via dimorphisms among DR beta-chain residues 67, 71, and 86. However, they differ markedly in their abilities to induce proliferation of DR(alpha,beta 1*1101)-restricted, peptide-specific T cell...
Topics
- Alleles
- Amino Acid Sequence
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Humans
- Lymphocyte Activation
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Peptides
- Protein Binding
- Structure-Activity Relationship
- T-Lymphocytes