Article
Alterations of p16/MTS1 gene in oral squamous cell carcinomas from Taiwanese.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Apr 2000
Lin S C, Chang K W, Chang C S, Liu T Y, Tzeng Y S, Yang F S, Wong Y K
Abstract excerpt
To determine the alterations of the p16/MTS1 gene in oral squamous cell carcinoma (OSCC), we examined in Taiwanese patients the mutation, deletion and methylation of p16/MTS1 in primary OSCCs associated mostly with betel quid (BQ)/tobacco use. Among 110 tumors undergoing mutational analyses, seven (6%) showed mutations in exon 2 or the intron 1/exon 2 splice site. All but one mutation disrupted the encoded...
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